Plasma exchange (plasmapheresis plus infusion of donor plasma) is used to remove the antibodies that are affecting clotting from the blood. It also replace the missing enzyme.
First, you will have your blood drawn as if you were donating blood.
The plasma portion of the blood will be passed through a cell separator. The remaining portion of the blood will be saved.
Plasma will be added to it, and the blood will be returned to you through a transfusion.
This treatment is repeated daily until blood tests show improvement.
People who do not respond to this treatment or whose condition often returns may need to:
Have surgery to remove their spleen
Get drugs that suppress the immune system, such as corticosteroids or rituximab
Plasma exchange has greatly improved the outcome of this disease. Most people can recover completely. However, some people die from this disease, especially if it is not diagnosed immediately. In people who don't recover, this condition can become long-term (chronic).
Call your health care provider if you have any unexplained bleeding.
Because the cause is unknown, there is no known way to prevent this condition.
McCrae KR, Sadler JE, Cines DB. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 136.