Symptoms of dermatitis herpetiformis tend to come and go. Symptoms include:
Extremely itchy bumps or blisters, most often on the elbows, knees, back, and buttocks
The rash is usually the same size and shape on both sides
The rash can look like eczema
Some patients may have scratch marks instead of blisters
Exams and Tests
A skin biopsy and direct immunofluorescence test of the skin are performed in most cases. Your doctor may also recommend a biopsy of the intestines. Blood tests may be ordered to confirm the diagnosis.
An antibiotic called dapsone is extremely effective.
A strict gluten-free diet will also be recommended to help control the disease. Sticking to this diet may eliminate the need for medications and prevent later complications.
Immunosuppressive medications may be used, but are less effective.
The disease may be well-controlled with treatment. Without treatment, there may be a significant risk of intestinal cancer.
Thyroid disease may be found in many patients with dermatitis herpetiformis. Patients are also more likely to develop certain cancers of the intestines.
When to Contact a Medical Professional
Call your health care provider if you have a rash that continues despite home treatment.
There is no known prevention of this disease. People with this condition may be able to prevent complications by avoiding foods that contain gluten.
Hull CM, Zone JJ. Dermatitis herpetiformis and linear IgA bullous dermatosis. In: Bolognia JL, Jorizzo JL, Schaffer JV, eds. Dermatology. 3rd ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 31.
Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Philadelphia, Pa: Elsevier Mosby; 2009:chap 16.
Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.